What is Acetylglucosamine NAG?
Acetylglucosamine NAG, also termed as Nagalase, is an enzyme that is produced by cancer cells and viruses. It is used to break down a sugar molecule called Gc-protein or vitamin D, which controls the growth of cancer cells and defends the body against viruses and bacteria.
The structure of Acetylglucosamine NAG
Acetylglucosamine NAG, with a molecular weight of 1,672 Da, has a hexagonal structure. It is composed of a sugar molecule called N-acetyl glucosamine and an acetyl group. The enzyme is highly active and can cleave several molecules of Gc-protein at a speed of 1000:1, which makes it a highly effective strategy for cancer and viral cells to evade the immune system.
The function of Acetylglucosamine NAG
In cancer, Nagalase is produced by cancer cells, and its function is to break down Gc-protein, a precursor of the vitamin D-binding protein. This results in the reciprocal reduction of vitamin D levels that, in turn, leads to a myriad of chronic diseases, such as autoimmune disorders, heart disease, and a higher risk of cancer. In viral infections, Nagalase is produced by infected cells, and it helps the virus to escape the immune system by breaking down Gc-protein and reducing vitamin D levels.
Research on Acetylglucosamine NAG
Research shows that measuring the levels of Nagalase in the blood may be a promising diagnostic tool for detecting and monitoring cancer. Moreover, inhibiting the activity of Nagalase has been explored as a therapeutic strategy for cancer, autoimmune disorders, and viral infections. Several natural compounds, such as curcumin, green tea extracts, and selenium, have been shown to inhibit Nagalase activity. Furthermore, a clinical trial of Gc-protein-derived macrophage-activating factor, a product that reverses the Nagalase activity, showed promising results in the treatment of breast and prostate cancers.
Conclusion
Acetylglucosamine NAG, or Nagalase, is an enzyme produced by cancer cells and infected cells to evade the immune system and promote the progression of cancer and viral infections. Research on Nagalase inhibitors as diagnostic and therapeutic strategies is promising and may offer new avenues for cancer and viral treatments.
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